Last update :
08/11/2024
References   References 2228  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2750

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Kupiec T, Ben M, Trusley C, Trissel LA.
Title : Compatibility and stability of palonosetron hydrochloride with gentamicin, metronidazole, or vancomycin during simulated Y-site administration.
Reference : Int J Pharm Compound ; 12,2: 170-173. 2008

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionGentamicin sulfate 5 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionMetronidazole 5 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionVancomycin hydrochloride 5 mg/ml + Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 26.7 µg/ml
injection Gentamicin sulfate 5.26 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 25 µg/ml
injection Metronidazole 2.6 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 27 µg/ml
injection Vancomycin hydrochloride 4.9 mg/ml
4 Hour

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