Last update :
19/11/2024
References   References 2176  
Type : Journal

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Barcia E, Martin A, Azuara ML, Sanchez Y, Negro S.
Title : Tramadol and hyoscine N-butyl bromide combined in infusion solutions: compatibility and stability.
Reference : Support Care Cancer ; 15: 57-62. 2007

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Mass balance PH measurement 
Comments : 

List of drugs
injectionScopolamine N-butyl bromide Antimuscarinic
Compatible 3,33>>6,67 mg/ml + injectionTramadol hydrochloride 8,33>>33,3 mg/ml + Sodium chloride 0,9%
injectionTramadol hydrochloride Analgesic
Compatible 8,33>>33,3 mg/ml + injectionScopolamine N-butyl bromide 3,33>>6,67 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
injection Tramadol hydrochloride 8,33>>33,3 mg/ml
injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
15 Day
Polypropylene Sodium chloride 0,9% 4°C Protect from light
injection Tramadol hydrochloride 8,33>>33,3 mg/ml
injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
15 Day

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