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References   References 2083  
Type : Journal
Research teams : Adelaide - Royal Adelaide Hospital, Department of Pharmacy
Authors : La Forgia SP, Sharley NA, Burgess NG, Doecke CJ.
Title : Stability and compatibility of morphine, midazolam and bupivacaine combinaisons for iontravenous infusion.
Reference : J Pharm Pract and Res ; 32: 65-68. 2002
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionMidazolam hydrochloride Anxiolytic
injectionMorphine tartrate Analgesic
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 22°C Protect from light
injection Morphine tartrate 1 mg/ml
injection Midazolam hydrochloride 0,5 mg/ml
28 Day
Not specified Sodium chloride 0,9% 22°C Protect from light
injection Morphine tartrate 1 mg/ml
injection Midazolam hydrochloride 0,5 mg/ml
injection Bupivacaine hydrochloride 4 mg/ml
28 Day
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