Last update :
08/11/2024
References   References 2064  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2325

Research teams : Geneva - University Hospital of Geneva
Authors : Nguyen-Xuan Tho, Griffiths W, Kern C, Van Gessel E, Bonnabry P.
Title : Stability of morphine sulfate in polypropylene infusion bags for use in patient-controlled analgesia pumps for postoperative pain management.
Reference : Int J Pharm Compound ; 10: 69-73. 2006

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Degradation products identified and quantified

List of drugs
injectionMorphine sulfate Analgesic
Stability in solutions Polypropylene Sodium chloride 0,9% 1 mg/ml 25°C Not specified
1095 Day

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