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References   References 199  
Type : Journal
Research teams : Baltimore - University of Maryland, School of Pharmacy
Authors : Hassan E, Leslie J, Martir-Herrero ML.
Title : Stability of labetalol hydrochloride with selected critical care drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 51: 2143-2145. 1994
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionDobutamine hydrochloride Cardiotonic
Compatible 2.5 mg/ml + injectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + injectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
injectionLabetalol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionDobutamine hydrochloride 2.5 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionDopamine hydrochloride 1.6 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionMorphine sulfate 0.5 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionNitroglycerin 0.2 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionRanitidine hydrochloride 0.6 mg/ml + Glucose 5%
injectionMorphine sulfate Analgesic
Compatible 0.5 mg/ml + injectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0.2 mg/ml + injectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.6 mg/ml + injectionLabetalol hydrochloride 1 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 20°C-25°C Light
injection Labetalol hydrochloride 1 mg/ml
injection Dobutamine hydrochloride 2,5 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
injection Labetalol hydrochloride 1 mg/ml
injection Dopamine hydrochloride 1,6 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
injection Labetalol hydrochloride 1 mg/ml
injection Morphine sulfate 0,5 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
injection Labetalol hydrochloride 1 mg/ml
injection Nitroglycerin 0,2 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Light
injection Labetalol hydrochloride 1 mg/ml
injection Ranitidine hydrochloride 0,6 mg/ml
4 Hour
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