Last update :
19/11/2024
References   References 1928  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S0885392404002593

Research teams : Paris - University Hospital Pitié-Salpétrière,Department of pharmacy
Authors : Alvarez JC, De Mazancourt Ph, Chartier-Kastler E, Denys P.
Title : Drug stability testing to support clinical feasibility investigations for intrathecal baclofen-clonidine admixture.
Reference : J Pain Symptom Manage ; 28, 3: 268-272. 2004

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Stability indicating capability inadequately assessed

List of drugs
injectionBaclofen Various
injectionClonidine hydrochloride Antihypertensive
Stability of mixtures
Glass Sodium chloride 0,9% 37°C Not specified
injection Clonidine hydrochloride 0,25 & 0,5 mg/ml
injection Baclofen 0,25 & 0,5 mg/ml
84 Day

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