Last update :
08/11/2024
References   References 1866  
Type : Journal

Research teams : Ghent - laboratory of Pharmaceutical technology, State University of Gent
Authors : Vermeire A, Remon JP.
Title : Compatibility and stability of morphine in binary admixtures with haloperidol, midazolam, dexamethasone or methylprednisolone.
Reference : Int J Pharm ; 174: 157-177. 1998

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 0.5 >> 20 mg/ml + injectionMorphine hydrochloride 1 >> 50 mg/ml + Sodium chloride 0,9%
injectionHaloperidol lactate Neuroleptic
Compatible 1 mg/ml + injectionMorphine hydrochloride 1 >> 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMorphine hydrochloride 1 >> 10 mg/ml + Sodium chloride 0,9%
Compatible 3 mg/ml + injectionMorphine hydrochloride 1 >> 3 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + injectionMorphine hydrochloride 1 & 2 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionMorphine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 2 mg/ml + injectionMorphine hydrochloride 15 > 50 mg/ml + Sodium chloride 0,9%
Incompatible 3 mg/ml + injectionMorphine hydrochloride 5 > 50 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionMorphine hydrochloride 3 > 50 mg/ml + Sodium chloride 0,9%
Incompatible 5 mg/ml + injectionMorphine hydrochloride 2 > 50 mg/ml + Sodium chloride 0,9%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 0.1 >> 9 mg/ml + injectionMorphine hydrochloride 10 >> 50 mg/ml + Sodium chloride 0,9%
Compatible 0.1 >> 9 mg/ml + injectionMorphine hydrochloride <10 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Compatible 1 >> 3 mg/ml + injectionMorphine hydrochloride 10 >> 40 mg/ml + Sodium chloride 0,9%
Incompatible 1 >> 3 mg/ml + injectionMorphine hydrochloride > 40 mg/ml + Sodium chloride 0,9%
Incompatible > 4 mg/ml + injectionMorphine hydrochloride > 30 mg/ml + Sodium chloride 0,9%
injectionMorphine hydrochloride Analgesic
Incompatible 1 >> 50 mg/ml + injectionDexamethasone sodium phosphate 0.5 >> 20 mg/ml + Sodium chloride 0,9%
Compatible 1 >> 20 mg/ml + injectionHaloperidol lactate 1 mg/ml + Sodium chloride 0,9%
Compatible 1 >> 10 mg/ml + injectionHaloperidol lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 1 >> 3 mg/ml + injectionHaloperidol lactate 3 mg/ml + Sodium chloride 0,9%
Compatible 1 & 2 mg/ml + injectionHaloperidol lactate 4 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionHaloperidol lactate 5 mg/ml + Sodium chloride 0,9%
Incompatible 15 > 50 mg/ml + injectionHaloperidol lactate 2 mg/ml + Sodium chloride 0,9%
Incompatible 5 > 50 mg/ml + injectionHaloperidol lactate 3 mg/ml + Sodium chloride 0,9%
Incompatible 3 > 50 mg/ml + injectionHaloperidol lactate 4 mg/ml + Sodium chloride 0,9%
Incompatible 2 > 50 mg/ml + injectionHaloperidol lactate 5 mg/ml + Sodium chloride 0,9%
Incompatible 10 >> 50 mg/ml + injectionMethylprednisolone sodium succinate 0.1 >> 9 mg/ml + Sodium chloride 0,9%
Compatible <10 mg/ml + injectionMethylprednisolone sodium succinate 0.1 >> 9 mg/ml + Sodium chloride 0,9%
Compatible 10 >> 40 mg/ml + injectionMidazolam hydrochloride 1 >> 3 mg/ml + Sodium chloride 0,9%
Incompatible > 40 mg/ml + injectionMidazolam hydrochloride 1 >> 3 mg/ml + Sodium chloride 0,9%
Incompatible > 30 mg/ml + injectionMidazolam hydrochloride > 4 mg/ml + Sodium chloride 0,9%

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