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References   References 1690  
Type : Journal
Research teams : Bad Homburg - Fresenius AG, Innovation-Zentrum IV Therapien
Authors : Müller H-J, Berg J.
Title : Stabilitätsstudie zu tramadolhydrochlorid im PVC-infusionbeutel.
Reference : Krankenhauspharmazie ; 18: 75-79. 1997
Level of Evidence : 
Level of evidence B+
Physical stability : 
Particle counting Visual examination 
Chemical stability : 
ultraviolet spectrometry
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
injectionTramadol hydrochloride Analgesic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 & 4 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 & 4 mg/ml 25°C With or without light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 & 4 mg/ml 40°C Protect from light
7 Day
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