Last update :
14/12/2024
References   References 1678  
Type : Journal

Research teams : Parkville - Monash University, Victorian College of Pharmacy
Authors : Sitaram BR, Tsui M, Rawicki HB, Lam S, Sitaram M.
Title : Stability and compatibility of intrathecal admixtures containing baclofen and high concentrations of morphine.
Reference : Int J Pharm ; 153: 13-24. 1997

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - fluorescence detector
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Measurement of osmolality PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
injectionBaclofen Various
Compatible 0.2 >> 1.5 mg/ml + injectionMorphine sulfate 7.5 >> 21 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 7.5 >> 21 mg/ml + injectionBaclofen 0.2 >> 1.5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 37°C Not specified
injection Morphine sulfate 7,5 mg/ml
injection Baclofen 1,5 mg/ml
30 Day
Glass Sodium chloride 0,9% 37°C Not specified
injection Morphine sulfate 15 mg/ml
injection Baclofen 1 mg/ml
30 Day
Glass Sodium chloride 0,9% 37°C Not specified
injection Morphine sulfate 21 mg/ml
injection Baclofen 0,2 mg/ml
30 Day

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