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References   References 1633  
Type : Journal
Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Law S.
Title : Stability and compatibility of granisetron alone and in combination with dexamethasone in 0.9% sodium chloride and 5% dextrose in water solutions.
Reference : Can J Hosp Pharm ; 55: 27-38. 2002
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.050 >> 0.350 mg/ml + injectionGranisetron hydrochloride 0.008 >> 0.053 mg/ml + NaCl 0,9% or Glucose 5%
injectionGranisetron hydrochloride Antiemetic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,02 & 0,06 mg/ml 23°C Not specified
35 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,02 & 0,06 mg/ml 4°C Protect from light
35 Day
Compatible 0.008 >> 0.053 mg/ml + injectionDexamethasone sodium phosphate 0.050 >> 0.350 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C Not specified
injection Granisetron hydrochloride 0,02 & 0,06 mg/ml
injection Dexamethasone sodium phosphate 0,08 & 0,20 mg/ml
35 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Granisetron hydrochloride 0,02 & 0,06 mg/ml
injection Dexamethasone sodium phosphate 0,08 & 0,20 mg/ml
35 Day
  Mentions Légales