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References   References 1286  
Type : Journal
Web link : https://doi.org/10.1345/aph.17400
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Xu QA, Gilbert DL.
Title : Compatibility and stability of paclitaxel combined with doxorubicin hydrochloride in infusion solutions.
Reference : Ann Pharmacotherapy ; 32: 1013-1016. 1998
Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence A+ Paclitaxel
Level of evidence B+ Doxorubicin hydrochloride
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 90% of the initial concentrationDoxorubicin hydrochloride
Stability defined as 95% of the initial concentrationPaclitaxel
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Paclitaxel
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Doxorubicin hydrochloride
Other methods : 
Comments : 
No comments for the degradation productsPaclitaxel
No comments for the degradation productsDoxorubicin hydrochloride
List of drugs
injectionDoxorubicin hydrochloride Anticancer drug
Compatible 0,2 mg/ml + injectionPaclitaxel 0,3 & 1,2 mg/ml + NaCl 0,9% or Glucose 5%
injectionPaclitaxel Anticancer drug
Compatible 0,3 & 1,2 mg/ml + injectionDoxorubicin hydrochloride 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyolefine NaCl 0,9% or Glucose 5% 23°C Light
injection Doxorubicin hydrochloride 0,2 mg/ml
injection Paclitaxel 0,3 & 1,2 mg/ml
24 Hour
Polyolefine NaCl 0,9% or Glucose 5% 32°C Light
injection Paclitaxel 0,3 & 1,2 mg/ml
injection Doxorubicin hydrochloride 0,2 mg/ml
24 Hour
Polyolefine NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Paclitaxel 0,3 & 1,2 mg/ml
injection Doxorubicin hydrochloride 0,2 mg/ml
24 Hour
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