Last update :
19/11/2024
References   References 1276  
Type : Journal

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Shiffman E, Walker SE, Yoon T, Yeung M.
Title : Stability and compatibility of morphine with bupivacaine.
Reference : Can J Hosp Pharm ; 51: 110-116. 1998

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Increased concentration unexplained

List of drugs
injectionBupivacaine hydrochloride Local anesthetic
Compatible 1 mg/ml + injectionMorphine sulfate 0,05 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 0,05 mg/ml + injectionBupivacaine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Not specified Sodium chloride 0,9% 23°C Light
injection Morphine sulfate 0,05 mg/ml
injection Bupivacaine hydrochloride 1 mg/ml
28 Day
Not specified Sodium chloride 0,9% 4°C Protect from light
injection Morphine sulfate 0,05 mg/ml
injection Bupivacaine hydrochloride 1 mg/ml
28 Day

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