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Anticancer drug   Melphalan  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Alkeran Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, France, Germany, Great Britain, Greece, Ireland, Italy, Luxembourg, Malaysia, New Zealand, Sweden, Switzerland, United Arab Emirates, United States of America
Egymelan Peru
Eriolan Argentina, Ecuador
Melfalan Argentina, Chile, Ecuador, Germany, Spain
Melfoma Argentina, Peru
Stability in solutions   injection   Stability in solutions : Melphalan     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 0,06 mg/ml 23°C Protect from light
1 Hour
1501
Level of evidence A
Glass Sodium chloride 0,9% 0,06 mg/ml 4°C Protect from light
24 Hour
1501
Level of evidence A
Glass specific solvent 5 mg/ml 23°C Not specified
6 Hour
4189
Level of evidence C
Polyvinyl chloride Water for Injection 0,2 mg/ml -20°C Protect from light
72 Hour
160
Level of evidence B
Polyvinyl chloride Water for Injection 0,2 mg/ml 4°C Protect from light
6 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,06 mg/ml 23°C Protect from light
1 Hour
1501
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,06 mg/ml 4°C Protect from light
24 Hour
1501
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,2 mg/ml -20°C Protect from light
72 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,2 mg/ml 4°C Protect from light
6 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,5 mg/ml 23-27°C Light
2 Hour
3977
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 23°C Not specified
1 Hour
4189
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 4°C Not specified
2 Hour
4189
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1,5 & 2 mg/ml 23°C Not specified
2 Hour
4189
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1,5 & 2 mg/ml 4°C Not specified
2 Hour
4189
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 2-8°C Protect from light
24 Hour
3977
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 23-27°C Light
6 Hour
3977
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 4 mg/ml 2-8°C Protect from light
2 Hour
3977
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 4 mg/ml 23-27°C Light
8 Hour
3977
Level of evidence D
Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml -20°C Protect from light
72 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 20°C Light
12 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 23°C Light
5 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 26°C Light
3 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 4°C Protect from light
48 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 3% 2 mg/ml 23°C Light
4 Hour
160
Level of evidence B
Polyvinyl chloride Sodium chloride 3% 2 mg/ml 26°C Light
3 Hour
160
Level of evidence B
Polyethylene Sodium chloride 0,9% 0,06 mg/ml 21°C-22°C Not specified
2 Hour
1520
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,06 mg/ml 23°C Protect from light
1 Hour
1501
Level of evidence A
Polyethylene Sodium chloride 0,9% 0,06 mg/ml 4°C Protect from light
24 Hour
1501
Level of evidence A
Polyethylene Sodium chloride 0,9% 0,06 mg/ml 4°C Not specified
24 Hour
1520
Manufacturer's stability data
Polypropylene NaCl 0.9% (4°C) 2 mg/ml 4°C Light
4 Hour
3516
Level of evidence C
Polypropylen Syringe Sodium chloride 0,9% 0,015 mg/ml -18°C Not specified
28 Day
3949
Level of evidence C
Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml -18°C Not specified
28 Day
3949
Level of evidence C
Not specified Sodium chloride 0,9% 0,3 mg/ml -20°C Protect from light
180 Day
3786
Level of evidence D
  Mentions Légales