Monographie - Melphalan

Última actualização :
05/12/2025

Melphalan

estrutura química

Nomes comerciais nos diversos países

OS NOMES COMERCIAIS SÃO INDICATIVOS E OS EXCIPIENTES DA FORMULAÇÃO PODEM SER DIFERENTES CONFORME O PAÍS E FABRICANTE.

Alkeran	Alemanha, Bélgica, Brasil, Canadá, Chilli, Colômbia, Emirados Árabes Unidos, Estados Unidos de América, França, Grècia, Irã, Irlanda, Itália, Luxemburgo, Malásia, nova Zelândia, Países Baixos, Suècia, Suicia
Egymelan	Peru
Eriolan	Argentina, Equator
Melfalan	Alemanha, Argentina, Chilli, Equator, Espanha
Melfoma	Argentina, Peru
Melkayl	Chilli
Melphalan	Gran-bretanha
Phelinun	Alemanha

Bibliografía : Melphalan

	tipo	publicação
84	jornal	Trissel LA, Martinez JF. Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection. Am J Hosp Pharm 1994 ; 51: 495-499.
160	jornal	Pinguet F, Martel P, Rouanet P, Fabbro M, Astre C. Effect of sodium chloride concentration and temperature on melphalan stability during storage and use. Am J Hosp Pharm 1994 ; 51: 2701-2704.
169	jornal	Trissel LA, Martinez JF. Physical compatibility of melphalan with selected drugs during simulated Y-site administration. Am J Hosp Pharm 1993 ; 50: 2359-2363.
182	jornal	Trissel LA, Gilbert DL, Martinez JF. Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 1997 ; 54: 56-60.
244	jornal	Trissel LA, Martinez JF. Compatibility of filgrastim with selected drugs during simulated Y-site administration. Am J Hosp Pharm 1994 ; 51: 1907-1913.
307	jornal	Trissel LA, Martinez JF. Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration. Am J Hosp Pharm 1994 ; 51: 1792-1799.
854	jornal	Chang SY, Evans TL, Alberts DS. The stability of melphalan in the presence of chloride ion. J Pharm Pharmacol 1979 ; 31: 853-854.
905	jornal	Trissel LA, Martinez JF. Screening teniposide for Y-site physical incompatibilities. Hosp Pharm 1994 ; 29: 1010-1017.
1501	jornal	Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M. Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials. Int J Pharm 1999 ; 185: 113-121.
1520	Laboratório	Etude de stabilité des médicaments en Ecoflac® B Braun 2001
2247	jornal	Chan P, Heatherly K, Kupiec T.C, Trissel L.A. Compatibility of caspofungin acetate injection with other drugs during simulated Y-site coadministration. Int J Pharm Compound 2008 ; 12, 3: 276-278.
3516	poster	Vigneron J, Zenier H, May I, Nicolas A. Stabilité du melphalan à 2 mg/ml dans le chlorure de sodium 0,9% dans des conditions pratiques d'utilisation. SFPO Congress, Mandelieu, France. 2013
3584	Laboratório	Melphalan (Alkéran®) - Résumé des caractéristiques du produit Aspen Pharma 2013
3786	jornal	Buitrago E, Lagomarsino E; Mato G; Schaiquevich P. Stability of Melphalan Solution for Intravitreal Injection for Retinoblastoma JAMA Ophtalmology 2014 ; 132, 11: 1372-1373.
3949	poster	Brönnimann C, Berger-Gryllaki M, Podilsky G, Sadeghipour F. Optimisation du processus de préparation des solutions de melphalan destinées à l’administration intra-vitréenne dans le traitement du rétinoblastome et étude de leur stabilité JFSPH Congress, Bern, Switzerland. 2016
3977	jornal	Desmaris R.P, Mercier L, Paci A. Stability of Melphalan in 0,9% Sodium Chloride Solutions Prepared in Polyvinyl Chloride Bags for Intravenous Injection. Drugs R D 2015 ;15:253-259.
4189	jornal	Kawedia J, Ramchandran S, Liu X, Gulbis A, Titus M, Bashir Q, Qazilbash M, Champlin R, Ciur S, Stability of Captisol-enabled versus propylene glycol–based melphalan at room temperature and after refrigeration. Am J Health-Syst Pharm 2022 ;79,12: 1011-1018
4376	jornal	Shi Z, Abruzzo T, Wanasathop A, Li S K. Compatibility of Melphalan in Iodinated Contrast Media. Int J Pharm Compound 2020 ;24,1:83-85
4701	jornal	Singh R, Chen J, Miller T, Bergren M, Mallik R. Solution stability of Captisol-stabilized melphalan (Evomela) versus Propylene glycol-based melphalan hydrochloride injection. Pharm Dev Technol 2018 ; 23, 10: 1024-1029.

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