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19/11/2024
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Anticancer drug   Etoposide  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Eposin Belgium, Colombia, Great Britain, Malaysia, Norway, Republic of South Africa, Sweden
Etocris Argentina, Chile, Peru
Etolon India
Etomedac Germany, Luxembourg
Etonolver Venezuela
Etoposide France, Greece, Netherlands
Etosid Egypt, India, Malaysia
Eunades Brazil
Euvaxon Argentina
Exitop Finland, Germany, Sweden
Fytosid Egypt, India, Malaysia
Lastet Egypt, Hungary, Iran, Italy, Poland, Turkey, United Arab Emirates
Onkoposid Germany
Riboposid Germany
Sedol Peru
Toposin Netherlands
Tosuben Mexico
Vepesid Australia, Austria, Belgium, Canada, Colombia, Croatia, Denmark, Egypt, Finland, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, Netherlands, Poland, Republic of South Africa, Saudi Arabia, Slovenia, Spain, Switzerland, Turkey, United States of America
Vepeside Morocco, Tunisia
Stability in solutions   injection   Stability in solutions : Etoposide     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 0,2 mg/ml ? Not specified
7 Day
504
Level of evidence A
Glass NaCl 0,9% or Glucose 5% 0,4 mg/ml 20°C-22°C Light
4 Day
482
Level of evidence A
Glass Sodium chloride 0,9% 0,2 mg/ml 24°C Light
22 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 0,2 mg/ml 4°C Protect from light
14 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 0,3 mg/ml 24°C Light
2 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 0,3 mg/ml 4°C Protect from light
7 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 0,4 mg/ml 24°C Not specified
24 Hour
161
Level of evidence B
Glass Sodium chloride 0,9% 0,4 mg/ml 24°C Light
24 Hour
1613
Level of evidence B
Glass Sodium chloride 0,9% 0,4 mg/ml 4°C Not specified
24 Hour
161
Level of evidence B
Glass Sodium chloride 0,9% 0,4 mg/ml 4°C Protect from light
2 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 10 mg/ml 24°C Light
5 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 10 mg/ml 4°C Protect from light
7 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 12 mg/ml 24°C Light
7 Day
1613
Level of evidence B
Glass Sodium chloride 0,9% 12 mg/ml 4°C Protect from light
14 Day
1613
Level of evidence B
Glass Ringer’s lactate solution 0,4 mg/ml 20°C-22°C Light
4 Day
482
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.25 mg/ml 8-12°C Not specified
21 Day
2167
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.4 mg/ml 20-23°C Light
7 Day
2167
Level of evidence D
Polyethylene NaCl 0,9% or Glucose 5% 0,05 & 0,2 mg/ml 20-25°C With or without light
7 Day
1722
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 0,05 & 0,2 mg/ml 25°C With or without light
8 Day
1520
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 0,05 & 0,2 mg/ml 4°C Protect from light
7 Day
1722
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 0,05 & 0,2 mg/ml 4°C With or without light
8 Day
1520
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,4 mg/ml 24°C Not specified
24 Hour
161
Level of evidence B
Polyethylene Sodium chloride 0,9% 0,4 mg/ml 4°C Not specified
24 Hour
161
Level of evidence B
Polypropylene Glucose 5% 0,157 mg/ml 25°C With or without light
48 Hour
152
Joker
Polypropylene Glucose 5% 0,157 mg/ml 4°C With or without light
48 Hour
152
Joker
Polyolefine NaCl 0,9% or Glucose 5% 0,4 mg/ml 23-27°C Light
21 Day
4369
Level of evidence A+
Polyolefine NaCl 0,9% or Glucose 5% 0,6 mg/ml 23-27°C Light
21 Day
4369
Level of evidence A+
Polyolefine Sodium chloride 0,9% 0,4 mg/ml 25°C Light
21 Day
4024
Level of evidence C
Polyolefine Sodium chloride 0,9% 0,6 mg/ml 25°C Light
21 Day
4024
Level of evidence C
Polyolefine Sodium chloride 0,9% 0.25 mg/ml 20°C Protect from light
5 Day
3670
Level of evidence A+
Polyolefine Glucose 5% 0,38 mg/ml 25°C Protect from light
61 Day
4125
Level of evidence A+
Polyolefine Glucose 5% 0,4 mg/ml 25°C Light
21 Day
4024
Level of evidence C
Polyolefine Glucose 5% 0,6 mg/ml 25°C Light
21 Day
4024
Level of evidence C
Polyolefine Glucose 5% 0,74 mg/ml 25°C Protect from light
61 Day
4125
Level of evidence A+
Polyolefine Glucose 5% 1,26 mg/ml 25°C Protect from light
61 Day
4125
Level of evidence A+
Polyolefine Glucose 5% 1,75 mg/ml 25°C Protect from light
28 Day
4125
Level of evidence A+
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,4 mg/ml 25°C Protect from light
24 Hour
4304
Level of evidence A
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,4 mg/ml 33°C Protect from light
24 Hour
4304
Level of evidence A
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,6 mg/ml 25°C Protect from light
8 Hour
4304
Level of evidence A
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,6 mg/ml 33°C Protect from light
6 Hour
4304
Level of evidence A
Polyisoprene elastomer Sodium chloride 0,9% 0,1 mg/ml 25°C Protect from light
24 Hour
4304
Level of evidence A
Polyisoprene elastomer Sodium chloride 0,9% 0,1 mg/ml 33°C Protect from light
24 Hour
4304
Level of evidence A
Polyisoprene elastomer Glucose 5% 0,1 mg/ml 25°C Protect from light
12 Hour
4304
Level of evidence A
Polyisoprene elastomer Glucose 5% 0,1 mg/ml 33°C Protect from light
12 Hour
4304
Level of evidence A
  Mentions Légales