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Anticancer drug   Doxorubicin hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Adriacept Germany
Adriamycin Australia, Austria, Canada, Denmark, Finland, Norway, United States of America
Adriblastin Austria, Switzerland
Adriblastina Belgium, Brazil, Croatia, Greece, Italy, Poland, Slovenia, Turkey
Adriblastine France, Greece
Adrimedac Germany
Biorub Brazil
Biorubina Poland
Dicladox Argentina
Doxolem Brazil
Doxorubicine France, Switzerland
Doxorubin Belgium, Greece
Farmiblastina Spain
Rastocin Poland
Robodoxo Germany
Stability in solutions   injection   Stability in solutions : Doxorubicin hydrochloride     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass Water for Injection 2 mg/ml -20°C Protect from light
30 Day
740
Level of evidence C
Glass Water for Injection 2 mg/ml 4°C Protect from light
180 Day
740
Level of evidence C
Glass NaCl 0,9% or Glucose 5% 0,1 mg/ml 20-25°C With or without light
4 Day
2256
Manufacturer's stability data
Glass NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 2-8°C Protect from light
28 Day
2256
Manufacturer's stability data
Glass NaCl 0,9% or Glucose 5% 1 mg/ml 20-25°C With or without light
28 Day
2256
Manufacturer's stability data
Glass Sodium chloride 0,9% 2 mg/ml 23°C Light
124 Day
681
Level of evidence C
Glass Sodium chloride 0,9% 2 mg/ml 4°C Light
124 Day
681
Level of evidence C
Glass Glucose 5% 0.015 mg/ml 49°C Protect from light
2 Hour
3706
Level of evidence D
Glass DC Beads® 15 mg/ml 2-8°C Protect from light
14 Day
3402
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,04 mg/ml 4°C Protect from light
7 Day
148
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml -20°C Protect from light
43 Day
686
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 20-25°C With or without light
4 Day
2256
Manufacturer's stability data
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 22°C Not specified
8 Day
1897
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 25°C Not specified
24 Day
686
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
43 Day
686
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
8 Day
1897
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 2-8°C Protect from light
28 Day
2256
Manufacturer's stability data
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 20-25°C With or without light
28 Day
2256
Manufacturer's stability data
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,4 mg/ml -20°C Protect from light
30 Day
859
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml -20°C Protect from light
14 Day
1237
Level of evidence C
Polyethylene NaCl 0,9% or Glucose 5% 0,1 mg/ml 20-25°C With or without light
4 Day
2256
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 0,1 mg/ml 25°C With or without light
8 Day
1520
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
8 Day
1520
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 2-8°C Protect from light
28 Day
2256
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 1 mg/ml 20-25°C With or without light
28 Day
2256
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,02 mg/ml 22°C Light
24 Hour
1897
Level of evidence D
Polyethylene Sodium chloride 0,9% 0,02 mg/ml 4°C Protect from light
24 Hour
1897
Level of evidence D
Polyethylene Glucose 5% 0,02 mg/ml 22°C Protect from light
8 Day
1897
Level of evidence D
Polyethylene Glucose 5% 0,02 mg/ml 25°C Protect from light
8 Day
1520
Manufacturer's stability data
Polyethylene Glucose 5% 0,02 mg/ml 4°C Protect from light
8 Day
1520
Manufacturer's stability data
Polyethylene Glucose 5% 0,02 mg/ml 4°C Protect from light
8 Day
1897
Level of evidence D
Polypropylene Glucose 5% 0,1 mg/ml 25°C Protect from light
28 Day
632
Level of evidence C
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 0,5 mg/ml 22°C Protect from light
14 Day
142
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 0,5 mg/ml 35°C Protect from light
14 Day
142
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 mg/ml 22°C Protect from light
28 Day
142
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 mg/ml 35°C Protect from light
7 Day
142
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 mg/ml 4°C Protect from light
28 Day
142
Joker
Ethylene vinyl acetate Sodium chloride 0,9% 0,5 mg/ml 4°C Protect from light
14 Day
142
Joker
Ethylene vinyl acetate Glucose 5% 0,5 mg/ml 4°C Protect from light
28 Day
142
Joker
Polypropylen Syringe Water for Injection 2 mg/ml 4°C Protect from light
43 Day
686
Level of evidence C
Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,1 mg/ml 20-25°C With or without light
4 Day
2256
Manufacturer's stability data
Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 2-8°C Protect from light
28 Day
2256
Manufacturer's stability data
Polypropylen Syringe NaCl 0,9% or Glucose 5% 1 mg/ml 20-25°C With or without light
28 Day
2256
Manufacturer's stability data
Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml 23°C Light
124 Day
681
Level of evidence C
Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml 4°C Protect from light
124 Day
681
Level of evidence C
Polypropylen Syringe None 2 mg/ml 2-8°C Protect from light
84 Day
3670
Level of evidence A+
  Mentions Légales