Last update :
29/10/2024
Antiemetic   Palonosetron hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aloxi Austria, Belgium, Canada, Denmark, Finland, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Netherlands, Norway, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Turkey, United States of America
Chepatron India
Cinvex Turkey
Factoket Mexico
Lotisa Turkey
Onicit Chile, Colombia, Ecuador, Italy, Peru
Palohalt Chile, Peru
Paloject Turkey
Palonosetron Belgium, Chile, Ecuador, France, Germany, Great Britain, Spain, Switzerland
Palostar India
Palzen India
Vinaltro Mexico
Viqet Mexico
Vonaxi Turkey
References   injection   References : Palonosetron hydrochloride  
Type Publication
1932 Journal Trissel LA, Zhang Y.
Compatibility and stability of Aloxi (palonosetron hydrochloride) admixed with dexamethasone sodium phosphate.
Int J Pharm Compound 2004 ; 8,5: 398-403.
1936 Journal Trissel LA, Xu QA.
Physical and chemical stability of palonosetron HCl in 4 infusion solusions.
Ann Pharmacotherapy 2004 ; 38: 1608-1611.
1940 Journal Xu QA, Trissel LA.
Stability of palonosetron hydrochloride with paclitaxel and docetaxel during simulated Y-site administration.
Am J Health-Syst Pharm 2004 ; 61: 1596-1598.
1950 Journal Trissel LA, Yanping Z.
Physical and chemical stability of palonosetron HCl with cisplatin, carboplatin and oxaliplatin during simulated Y-site administration.
J Oncol Pharm Practice 2004 ; 10: 191-195.
1955 Journal Trissel LA, Zhang Y.
Palonosetron HCl compatibility and stability with doxorubicin HCl and epirubicin HCl during simulated Y-site administration.
Ann Pharmacotherapy 2005 ; 39: 280-283.
1975 Journal Trissel LA, Xu QA.
Physical and chemical stability of palonosetron hydrochloride with lorazepam and midazolam hydrochloride during simulated Y-site administration.
Int J Pharm Compound 2005 ; 9, 3: 235-237.
1976 Journal Trissel LA, Xu QA.
Physical and chemical stability of palonosetron hydrochloride with topotecan hydrochloride and irinotecan hydrochloride during simulated Y-site administration.
Int J Pharm Compound 2005 ; 9, 3: 238-241.
2009 Journal Trissel LA, Zhang Y.
Physical and chemical stability of palonosetron hydrochloride with fluorouracil and with gemcitabine hydrochloride during simulated Y-site administration.
Int J Pharm Compound 2005 ; 2005, 9, 4: 320-322.
2016 Journal Xu QA, Trissel LA.
Compatibility of palonosetron with cyclophosphamide and with ifosfamide during Y-site administration.
Am J Health-Syst Pharm 2005 ; 62: 1998-2000.
2107 Journal Trissel LA, Zhang Y, Xu QA.
Physical and chemical stability of palonosetron hydrochloride with dacarbazine and with methylprednisolone sodium succinate during simulated Y-site administration.
Int J Pharm Compound 2006 ; 10: 234-236.
2179 Journal Trusley C, Ben M, Kupiec TC, Trissel LA.
Physical and chemical stability of palonosetron with metoclopramide and promethazine during simulated Y-site administration.
Int J Pharm Compound 2007 ; 11, 1: 82-85.
2196 Journal Trissel LA, Trusley C, Ben M, Kupiec TC.
Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during Y-site administration.
Am J Health-Syst Pharm 2007 ; 64, 11: 1209-1213.
2214 Journal Ben M, Trusley C,Kupiec T.C, Trissel L.A.
Palonosetron hydrochloride compatibility and stability with three beta-lactam antibiotics during simulated Y-site administration.
Int J Pharm Compound 2007 ; 11, 6: 520-524.
2227 Journal Trusley C, Ben M, Kupiec TC, Trissel LA.
Compatibility and stability of palonosetron hydrochloride with four neuromuscular blocking agents during simulated Y-site administration.
Int J Pharm Compound 2008 ; 12, 2: 156-160.
2228 Journal Kupiec T, Ben M, Trusley C, Trissel LA.
Compatibility and stability of palonosetron hydrochloride with gentamicin, metronidazole, or vancomycin during simulated Y-site administration.
Int J Pharm Compound 2008 ; 12,2: 170-173.
2279 Journal Kupiec T, Trusley C, Ben M, Trissel LA.
Physical and chemical stability of palonosetron hydrochloride with five common parenteral drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2008 ; 65, 18: 1735-1759.
2281 Journal Ben M, Kupiec T, Trusley C, Trisel LA.
Compatibility and stability of palonosetron hydrochloride with lactated Ringer's, Hetastarch in lactated electrolyte, an mannitol injections during simulated Y-site administration.
Int J Pharm Compound 2008 ; 12, 5: 460-462.
2286 Journal Ben M, Trusley C, Kupiec TC, Trissel LA.
Physical and chemical stability of palonosetron hydrochloride with glycopyrrolate and neostigmine during simulated Y-site administration.
Int J Pharm Compound 2008 ; 12, 4: 368-371.
2312 Journal Trissel L.A, Trusley C, Kupiec T.C, Ben M.
Compatibility and stability of palonosetron hydrochloride and propofol during simulated Y-site administration.
Int J Pharm Compound 2009 ; 13, 1: 78-80.
3459 Journal Sun S, Schaller J, Placek J, Duersch B.
Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids.
Cancer Chemother Pharmacol 2013 ; 72: 509-513.
3928 Journal Wu G, Yeung S, Chen F.
Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride.
Int J Pharm Compound 2017 ; 21, 1: 76-82.
3981 Journal He G, Zeng F, Lei K, Xia S, Deng L, Zhang C, Liu D.
Compatibility of dexamethasone sodium phosphate with 5-HT3 receptor antagonists in infusion solutions: a comprehensive study
EJHP 2017 ;24:162?166
4062 Journal Wu George, Powers Dan, Yeung S, Chen F, Neelon K.
Compatibility and stability of VARUBI (Rolapitant) injectable emulsion admixed with intravenous palonosetron hydrochloride injection and dexamethasone sodium phosphate injection.
Int J Pharm Compound 2018 ;22,1:76-85
4310 Journal Mizuta N, Nakagawa T, Yamamoto K, Nishioka T, Kume M, Makimoto H, Yano I, Minami H, Hiral M.
Compatibility and Stability of Nab-Paclitaxel in Combination with Other Drugs.
Kaohsiung J Med Sci 2017 ; 63, 1: E9-E16.

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