Monographie - Baclofen - Stabilis 4.0

Last update :
19/11/2024

Various

Baclofen

injection

Ointments

Oral solution

Stability in solutions

Stability of mixtures

Factors which affect stability

Compatibility

Route of administration

References

pdf

Chemical structure

Tradename

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Baclofen	Belgium, Germany, Great Britain, Spain, Switzerland
Gablofen	United States of America
Liofen	India
Lioresal	Argentina, Australia, Austria, Belgium, Canada, Denmark, France, Germany, Great Britain, Iceland, Italy, Luxembourg, Netherlands, New Zealand, Poland, Portugal, Spain, Sweden, Switzerland, United States of America
Val baclofen	Canada

References

injection

References : Baclofen

	Type	Publication
1467	Journal	Sitaram BR, Tsui M, Rawicki HB, Lam S, Courage P, Sitaram M, Chapman CB. Stability and compatibility of baclofen and morphine admixtures for use in an implantable infusion pump. Int J Pharm 1995 ; 118: 181-189.
1601	Journal	Godwin DA, Kim NH, Zuniga R. Stability of a baclofen and clonidine hydrochloride admixture for intrathecal administration. Hosp Pharm 2001 ; 36: 950-954.
1678	Journal	Sitaram BR, Tsui M, Rawicki HB, Lam S, Sitaram M. Stability and compatibility of intrathecal admixtures containing baclofen and high concentrations of morphine. Int J Pharm 1997 ; 153: 13-24.
1842	Journal	Sadjack A, Wintersteiger R. Compatibility of morphin, baclofen, floxuridine and fluorouracil in an implantable infusion pump. Arzneimittel Forschung 1995 ; 45: 93-98.
1928	Journal	Alvarez JC, De Mazancourt Ph, Chartier-Kastler E, Denys P. Drug stability testing to support clinical feasibility investigations for intrathecal baclofen-clonidine admixture. J Pain Symptom Manage 2004 ; 28, 3: 268-272.
2249	Journal	Shields D, Montenegro R, Aclan J. Chemical stability of admixtures combining ziconotide with baclofen during simulated intrathecal administration. Neuromodulation 2007 ; 10, 1: 12-17.
3683	Manufacturer	Baclofen - Résumé des caractéristiques du produit Aguettant 2014
3969	Journal	Yue B, Brendel R, Lukitsch A, Prentice T, Doty B. Solubility and stability of Baclofen 3 mg/mL intrathecal formulation and its compatibility with implantable programmable intrathecal infusion systems. Neuromodulation 2017
4051	Journal	Robert J, Sorrieul J, Kieffer H, Folliard C, Gibory V, Dupoiron D, Devys C. Stability study of morphine and baclofen solution in polypropylene syringes. Pharmaceutical Technology in Hospital Pharmacy 2017 ;2,4:173-180
4162	Journal	Sorrieul J, Robert J, Gibory V, Kieffer H, Folliard C, Dupoiron D, Devys C. Stability of sufentanil and baclofen mixtures for intrathecal analgesia at different concentrations in polypropylene syringes. Ann Pharm Fr 2018 ;76,6:444-452

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