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19/11/2024
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Anticancer drug   Busulfan  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Bucelon Peru
Busilvex Argentina, Belgium, Chile, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Mexico, Netherlands, Norway, Peru, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Turkey
Busulfan Germany
Busulfano Peru, Spain
Busulfex Canada, Malaysia, United States of America
Stability in solutions   injection   Stability in solutions : Busulfan     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 0.5 mg/ml 13-15°C Protect from light
36 Hour
2188
Level of evidence A
Glass Sodium chloride 0,9% 0.5 mg/ml 2-8°C Protect from light
48 Hour
2188
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 23°C Not specified
4 Hour
658
Level of evidence B+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 mg/ml 23°C Not specified
8 Hour
658
Level of evidence B+
Polypropylene Sodium chloride 0,9% 0.5 mg/ml 13-15°C Protect from light
36 Hour
2188
Level of evidence A
Polypropylene Sodium chloride 0,9% 0.5 mg/ml 2-8°C Protect from light
19 Hour
2188
Level of evidence A
Polyolefine NaCl 0,9% or Glucose 5% 0,5 mg/ml 23°C Not specified
8 Hour
658
Level of evidence B+
Polyolefine Sodium chloride 0,9% 0,12 mg/ml 25°C Not specified
12 Hour
3198
Level of evidence D
Polyolefine Sodium chloride 0,9% 0,12 mg/ml 4°C Not specified
12 Hour
3198
Level of evidence D
Polyolefine Sodium chloride 0,9% 0,24 mg/ml 25°C Not specified
8 Hour
3198
Level of evidence D
Polyolefine Sodium chloride 0,9% 0,24 mg/ml 4°C Not specified
16 Hour
3198
Level of evidence D
Polyolefine Glucose 5% 0,1 mg/ml 23°C Not specified
4 Hour
658
Level of evidence B+
Polypropylen Syringe Sodium chloride 0,9% 0,54 mg/ml 2-8°C Protect from light
30 Hour
4033
Level of evidence B
Polypropylen Syringe None 6 mg/ml 18°C-20°C Light
28 Day
2128
Level of evidence B
Polypropylen Syringe None 6 mg/ml 2-8°C Light
28 Day
2128
Level of evidence B
Polypropylen Syringe None 6 mg/ml 4°C Not specified
4 Day
3285
Level of evidence A+
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