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Anticancer drug   Busulfan  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Bucelon Peru
Busilvex Argentina, Belgium, Chile, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Mexico, Netherlands, Norway, Peru, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Turkey
Busulfan Germany
Busulfano Peru, Spain
Busulfex Canada, Malaysia, United States of America
References   injection   References : Busulfan  
Type Publication
658 Journal Xu QA, Zhang YP, Trissel LA, Martinez JF.
Stability of busulfan injection admixtures in 5% dextrose injection and 0.9% sodium chloride injection.
J Oncol Pharm Practice 1996 ; 2: 101-105.
2128 Journal Karstens A, Krämer I.
Untersuchungen zur Stabilität der Busulfan-Stammlösung (Busilvex®, Busulfex TM) in B/Braun Injekt® Einmalspritzen.
Pharmazie 2006 ; 10: 845-850.
2188 Journal Karstens A, Krämer I.
Chemical and physical stability of diluted busulfan infusion solutions.
EJHP Science 2007 ; 13, 2: 40-47
3198 Journal Nebot Martinez J, Alos Alminana M, Diez Sales O.
Estabilidad en suero fisiológico del busulfán intravenoso en un envase de poliolefinas.
Farm Hosp 2008 ; 32, 6 : 344-348.
3285 Journal Senoo M, Tajika K, Shimizu H, Hamada M, Dobashi Y, Dan K, Katayama S.
Development of New Mixing Method of Busulfex® Injecton for the Purpose of Improvement of Medical Safety Method; The Prefilled Syringe Method.
Yakugaku Zasshi 2009 129, 6: 767-771.
3868 Journal Loboda C, Lider P, Vigneron J.
Incompatibility of busulfan with 1 ml Luer-Lock syringes.
J Oncol Pharm Practice 2016 ; 22: 571-572
4033 Journal Guichard N, Bonnabry P, Rudaz S, Fleury-Souverain S.
Stability of busulfan solutions in polypropylene syringes and infusion bags as determined with an original assay.
Am J Health-Syst Pharm 2017 ;74,22:1887-1894
4398 Journal Smith E. K., Shergold J.A., McWhinney B.C.
Compatibility of intravenous busulfan with BBraun giving sets, fludarabine and Posiflush.
J Pharm Pract and Res 2020
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