Monographie - Metoprolol tartrate - Stabilis 4.0

Last update :
19/11/2024

Anti-arrhythmic

Metoprolol tartrate

injection

Oral solution

Stability in solutions

Stability of mixtures

Factors which affect stability

Compatibility

Route of administration

References

pdf

Chemical structure

Tradename

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Beloc	Austria, Switzerland, Turkey
Beloken	Spain
Betaloc	Great Britain, Poland
Lopresor	Canada
Selokeen	Netherlands
Seloken	Belgium, Brazil, Denmark, Finland, Italy, Norway, Sweden

References

injection

References : Metoprolol tartrate

	Type	Publication
62	Journal	Pugh CB, Pabis DJ, Rodriguez C. Visual compatibility of morphine sulfate and meperidine hydrochloride with other injectable drugs during simulated Y-site injection. Am J Hosp Pharm 1991 ; 48: 123-125.
238	Journal	Belliveau PP, Shea BF, Scavone JM. Stability of metoprolol tartrate in 5% dextrose injection or 0.9% sodium chloride injection. Am J Hosp Pharm 1993 ; 50: 950-952.
240	Journal	Lam XM, Ward CA, de C du M?e CPR. Stability and activity of alteplase with injectable drugs commonly used in cardiac therapy. Am J Health-Syst Pharm 1995 ; 52: 1904-1909.
921	Journal	Trissel LA, Gilbert DL, Martinez JF. Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration. Hosp Pharm 1998 ; 33: 284-292.
1944	Journal	Hartman CA, Faria CE, Mago K. Visual compatibility of bivalirudin with selected drugs. Am J Health-Syst Pharm 2004 ; 61: 1774.
1964	Journal	Hartman CA, Baroletti SA, Churchill WW et al. Visual compatibility of argatroban with selected drugs. Am J Health-Syst Pharm 2002 ; 59: 1784-1785.
2267	Journal	Kraft MD, Johnson CE, Chung C, Julian F. Stability of metoprolol tartrate injection 1 mg/ml undiluted and 0.5 mg/ml in 0.9% sodium chloride injection and 5% dextrose injection. Am J Health-Syst Pharm 2008 ; 65, 7: 636-638.
2269	Journal	Chan P, Bishop A, Kupiec TC, Trissel LA, Gole D, Jimidar IM, Vermeersch H. Compatibility of ceftobiprole medocaril with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 2008 ; 65, 16: 1545-1551.
2346	Journal	Newland A.M, Mauro V.F, Alexander K.S. Physical compatibility of metoprolol tartrate injection with selected cardiovascular agents Am J Health-Syst Pharm 2009 ; 66: 986-987.
3249	Journal	Singh BM, Dedhiya MG, Dinunzio J, Chan P, Kupiec TC, Trissel LA, Laudano JB. Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 2011 ; 68: 2163-2169.
3372	Journal	Hanci V, Ali Kiraz H, Ömür D, Ekin S, Uyan B, Yurtlu B.S. Precipitation in Gallipoli: Sugammadex / Amiodarone & Sugammadex / Dobutamine & Sugammadex / Protamine. Rev Bras Anestesiol 2013 ; 63, 1: 163-166.
3538	Journal	Gilcher Th, Heeb R M, Krämer I. Physikalisch-chemische Stabilität einer Metoprolol-Injektionslösung 1 mg/ml, 50 ml. Krankenhauspharmazie 2013 ; 11: 524-525.
3644	Manufacturer	Calcium gluconate® - Summary of Product Characteristics Hameln Pharmaceuticals 2010
3838	Manufacturer	Magnesium Sulphate - Summary of Product Characteristics Martindale Pharmaceuticals Ltd 2007
3879	Journal	Foushee Jaime A, Meredith Pmichaele, Fox Laura M, Grace Edward E. Y-site Physical Compatibility of Beta-blocker Infusions with Intensive Care Unit Admixtures. Int J Pharm Compound 2016 ; 20, 4 : 328-332.
3934	Manufacturer	Eptifibatide (Integrilin®) - Résumé des caractéristiques du produit GlaxoSmithKline Laboratoire 2016
4319	Journal	Lessard J-J, Caron E, Schérer H, Forest J-M, Leclair G. Compatibility of Y-site Injection of Meropenem Trihydrate With 101 Other Injectable Drugs. Hosp Pharm 2020 ; 55, 5: 332-337.
4433	Journal	Ghazi I.M, El Nekidy W.S, Sood A, Dulku A, Patel R, Patel K. Y-site Administration of Imipenem/Cilastatin/ Relebactam With Common Intravenous Medications Clin Ther 2020 ; 42, 3: 475-485.

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