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Cytoprotective   Levofolinate calcium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Calc Levof Italy
Calcium levofolinat Austria
Elvorine Belgium, France, Luxembourg, Morocco
Folaxin Spain
Folinate EG Belgium
Isovorin Austria, Denmark, Finland, Great Britain, Greece, Iceland, Spain, Sweden
Levofolatino de calcio Portugal
Levofolene Italy
References   injection   References : Levofolinate calcium  
Type Publication
3 Journal Trissel LA, Martinez JF.
Compatibility of amifostine with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
155 Journal Trissel LA, Martinez JF, Xu QA.
Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium.
Am J Health-Syst Pharm 1995 ; 52: 710-715.
1520 Manufacturer Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1914 Manufacturer Pemetrexed (Alimta®) - Summary of Product Characteristics
Eli Lilly 2016
2130 Journal Lokiec F, Amirault P, Bonnans H, Gauzan MF, Sauvage N, Santoni J.
Stabilité du mélange 5-fluoro-uracil-acide fonique : influence des concentrations, du contenant et de la forme de l’acide folinique.
Bull Cancer 1999 ; 86, 11: 946-954.
2181 Journal Milano G, Renée N.
Etude de compatibilité physicochimique 5- fluoro-uracile (nouvelle préparation française) - acide folinique.
Bull Cancer 1995 ; 82: 189-195.
2295 Manufacturer Fosaprepitant (Emend®) - Summary of Product Characteristics
Merck Sharp Dohme 2013
2361 Journal Lebitasy M, Hecq J.D, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L.
Effect of freeze-thawing on the long-term stability of calcium levofolinate in 5% dextrose stored on polyolefin infusion bags.
J Clin Pharm Ther 2009 ; 34, 4 : 423-428.
2531 Journal Sanogo S, Silimbani P, Gaggeri R, Masini C.
Stability of calcium levofolinate reconstituted in syringes and diluted in NaCl 0.9% and glucose 5% polyolefin/ polyamide infusion bags.
J Oncol Pharm Practice 2021 ; 27, 2: 288-296.
3369 Manufacturer Levofolinate de sodium Medac - Résumé des caractéristiques du produits
MEDAC France 2011
3523 Manufacturer Ceftriaxone (Rocephin®) - Summary of Product Characteristics.
Roche 2018
3546 Manufacturer Cefamandole Flavelab - Résumé des caractéristiques du produit
Panpharma SA 2007
3619 Manufacturer Pamidronate (Pamidronate Actavis®) - Summary of Product Characteristics
Wockhardt 2016
3621 Manufacturer Phosphate dipotassique - Résumé des caractéristiques du produit
Renaudin 2008
3662 Manufacturer Foscavir (Foscarnet®) - Summary of Product Characteristics
Clinigen 2014
3753 Manufacturer Tedizolid phosphate (Sivextro®) - Summary of Product Characteristics
Cubist Pharmaceuticals 2014
3838 Manufacturer Magnesium Sulphate - Summary of Product Characteristics
Martindale Pharmaceuticals Ltd 2007
3933 Manufacturer Acide zolédronique - (Acide zoledronique Teva Pharma) - Résumé des caractéristiques du produit
Teva Laboratoire 2015
4154 Manufacturer Bleomycin sulfate- Summary of Product Characteristics
Accord Health Care 2018
4720 Manufacturer Nuzyra (amadacycline - Full prescribing infomation. Paratek Pharmaceuticals updated May 2021.
Paratek Pharmaceuticals 2021
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