Monographie - Methadone hydrochloride - Stabilis 4.0

Last update :
19/11/2024

Analgesic

Methadone hydrochloride

injection

Oral solution

Stability in solutions

Stability of mixtures

Factors which affect stability

Compatibility

Route of administration

References

pdf

Chemical structure

Tradename

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Eptadone	Italy
Ketalgin	Switzerland
Mephenon	Belgium
Metasedin	Spain
Methadone
Physeptone	Great Britain

References

injection

References : Methadone hydrochloride

	Type	Publication
224	Journal	Denson DD, Crews JC, Grummich KW, Stirm EJ, Sue CA. Stability of methadone hydrochloride in 0.9% sodium chloride injection in single-dose plastic containers. Am J Hosp Pharm 1991 ; 48: 515-517.
1506	Journal	Lopez-Cabezas C, Guerrero L, Molas G, Anglada H, Soy D. Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units. EJHP 2015 ;22:107-112.
1974	Journal	Chandler SW, Trissel LA, Weinstein SM Combined administration of opoids with selected drugs to manage pain and other cancer symptoms initial safety screening for compatibility. J Pain Symptom Manage 1996 ; 12, 3: 168-171.
3470	Journal	Destro M, Ottolini L, Vicentini L, Boschetti S. Physical compatibility of binary and tertiary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care. Support Care Cancer 2012 ; 20: 2501-2509.
3504	Manufacturer	Parecoxib (Dynastat®) - Summary of Product Characteristics Pfizer 2012
4406	Journal	Friciu M, Alarie H, Beauchemin M, Forest JM, Leclair G. Stability of Methadone Hydrochloride for Injection in Saline Solution Can J Hosp Pharm 2020 2020;73(2):141-4

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