Last update :
19/11/2024
Anticancer drug   Nivolumab  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Opdivo Argentina, Belgium, Brazil, Chile, Finland, France, Germany, Great Britain, Hungary, Ireland, Italy, Japan, Luxembourg, Mexico, Norway, Peru, Romania, Slovenia, Spain, Sweden, Switzerland
Stability in solutions   injection   Stability in solutions : Nivolumab     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 1 >> 10 mg/ml 2-8°C Protect from light
30 Day
4652
Manufacturer's stability data

Glass Sodium chloride 0,9% 1 >> 10 mg/ml 25°C Light
24 Hour
4652
Manufacturer's stability data

Glass Glucose 5% 1 >> 10 mg/ml 2-8°C Protect from light
7 Day
4652
Manufacturer's stability data

Glass Glucose 5% 1 >> 10 mg/ml 25°C Light
8 Hour
4652
Manufacturer's stability data

Glass None 10 mg/ml 2-8°C Protect from light
7 Day
4025
Level of evidence B+

Glass None 10 mg/ml 25°C Light
48 Hour
4652
Manufacturer's stability data

Glass None 10 mg/ml 40°C Not specified
7 Day
4505
Level of evidence A+

partially used vials None 10 mg/ml 2-8°C Not specified
28 Day
4505
Level of evidence A+

Polyvinyl chloride Sodium chloride 0,9% 1 >> 10 mg/ml 2-8°C Protect from light
30 Day
4652
Manufacturer's stability data

Polyvinyl chloride Sodium chloride 0,9% 1 >> 10 mg/ml 25°C Light
24 Hour
4652
Manufacturer's stability data

Polyvinyl chloride Glucose 5% 1 >> 10 mg/ml 2-8°C Protect from light
7 Day
4652
Manufacturer's stability data

Polyvinyl chloride Glucose 5% 1 >> 10 mg/ml 25°C Light
8 Hour
4652
Manufacturer's stability data

Polyolefine Sodium chloride 0,9% 1 >> 10 mg/ml 2-8°C Protect from light
30 Day
4652
Manufacturer's stability data

Polyolefine Sodium chloride 0,9% 1 >> 10 mg/ml 25°C Light
24 Hour
4652
Manufacturer's stability data

Polyolefine Sodium chloride 0,9% 2 mg/ml 2-8°C Not specified
28 Day
4505
Level of evidence A+

Polyolefine Glucose 5% 1 >> 10 mg/ml 2-8°C Protect from light
7 Day
4652
Manufacturer's stability data

Polyolefine Glucose 5% 1 >> 10 mg/ml 25°C Light
8 Hour
4652
Manufacturer's stability data

Not specified Sodium chloride 0,9% 2 mg/ml 2-8°C Protect from light
28 Day
4025
Level of evidence B+


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