Last update :
03/05/2024
References   References 934  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=452

Research teams : Nagoya - Meijo University, Faculty of Pharmacy
Authors : Inagaki K, Kambara M, Mizuno M, Okuda J, Gill MA, Nishida M.
Title : Compatibility and stability of ranitidine hydrochloride with six cephalosporins during simulated Y-site administration.
Reference : Int J Pharm Compound ; 2: 318-321. 1998

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionCefmenoxime Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCefoperazone sodium Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCefuzonam Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionMoxalactam Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + InjectionCefmenoxime 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCefoperazone sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCeftizoxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCefuzonam 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionMoxalactam 20 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Moxalactam 10 mg/ml
2 Hour
Glass Sodium chloride 0,9% 25°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Ceftizoxime sodium 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 25°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Cefoperazone sodium 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 25°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Cefmenoxime 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 25°C Light
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Cefuzonam 10 mg/ml
4 Hour

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