Last update :
19/11/2024
References   References 930  
Type : Journal
Web link : https://doi.org/10.1046/j.1365-2710.1997.00113.x

Research teams : Singapore - Department of Pharmacy, Faculty of Science, National University of Singapore
Authors : Hor MMS, Chan SY, Yow KL, Lim LY, Chan E.
Title : Stability of admixtures of pethidine and metoclopramide in aqueous solution, 5% dextrose and 0.9% sodium chloride.
Reference : J Clin Pharm Ther ; 22: 339-345. 1997

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Increased concentration unexplained

List of drugs
injectionMetoclopramide hydrochloride Antiemetic
Compatible 0.15 mg/ml + injectionPethidine hydrochloride 7.35 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 6.67 mg/ml + injectionPethidine hydrochloride 16.67 mg/ml + None
injectionPethidine hydrochloride Analgesic
Compatible 7.35 mg/ml + injectionMetoclopramide hydrochloride 0.15 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 16.67 mg/ml + injectionMetoclopramide hydrochloride 6.67 mg/ml + None
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 32°C Not specified
injection Metoclopramide hydrochloride 0.15 mg/ml
injection Pethidine hydrochloride 7.35 mg/ml
48 Hour

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