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References   References 924  
Type : Journal
Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Brigas F, Sautou-Miranda V, Normand B, Geneve S, Chopineau J.
Title : Compatibility of tropisetron with glass and plastics. Stability under different storage conditions.
Reference : J Pharm Pharmacol ; 50: 407-411. 1998
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
List of drugs
InjectionTropisetron hydrochloride Antiemetic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,05 mg/ml 20-25°C With or without light
14 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,05 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 mg/ml 20-25°C With or without light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,05 mg/ml 20-25°C With or without light
14 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,05 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polypropylen Syringe None 1 mg/ml 20-25°C With or without light
14 Day
Stability in solutions Polypropylen Syringe None 1 mg/ml 4°C Protect from light
14 Day
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