Last update :
19/11/2024
References   References 913  
Type : Journal

Research teams : Birmingham - Queen Elisabeth Hospital, Pharmacy Department
Authors : Wood MJ, Lund R, Beavan M.
Title : Stability of vancomycin in plastic syringes measured by high-performance liquid chromatography.
Reference : J Clin Pharm Ther ; 20: 319-325. 1995

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products identified
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionVancomycin hydrochloride Antibiotic
Stability in solutions Polyethylene Water for Injection 10 mg/ml 25°C Protect from light
29 Day
Stability in solutions Polyethylene Water for Injection 10 mg/ml 4°C Protect from light
84 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Protect from light
33 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
84 Day
Stability in solutions Polypropylen Syringe Water for Injection 10 mg/ml 25°C Protect from light
47 Day
Stability in solutions Polypropylen Syringe Water for Injection 10 mg/ml 4°C Protect from light
84 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
84 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml 25°C Protect from light
62 Day
Stability in solutions Polypropylen Syringe Glucose 5% 10 mg/ml 25°C Protect from light
55 Day

  Mentions Légales