Last update :
29/10/2024
References   References 823  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/55/15/1584

Research teams : King of Prussia - SmithKline Beecham Pharmaceuticals
Authors : Patel K, Craig SB, McBride MG, Palepu NR.
Title : Microbial inhibitory properties and stability of topotecan hydrochloride injection.
Reference : Am J Health-Syst Pharm ; 55: 1584-1587. 1998

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
injectionTopotecan Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 5°C Protect from light
28 Day

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