Last update :
19/11/2024
References   References 779  
Type : Journal

Research teams : Swindon - Princess Margaret Hospital
Authors : Collins AJ, Abethell JA, Holmes SG, Rain R.
Title : Stability of diamorphine hydrochloride with haloperidol in prefilled syringes for continuous subcutaneous administration.
Reference : J Pharm Pharmacol ; 38: 51P. 1986

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionDiamorphine hydrochloride Analgesic
Compatible 6.25 & 12.5 mg/ml + injectionHaloperidol lactate 0.31 mg/ml + None
injectionHaloperidol lactate Neuroleptic
Compatible 0.31 mg/ml + injectionDiamorphine hydrochloride 6.25 & 12.5 mg/ml + None
Stability of mixtures
Polypropylen Syringe None 22°C-24°C With or without light
injection Diamorphine hydrochloride 6,25 & 12,5 mg/ml
injection Haloperidol lactate 0,31 mg/ml
24 Hour
Polypropylen Syringe None 4-8°C Protect from light
injection Diamorphine hydrochloride 6,25 & 12,5 mg/ml
injection Haloperidol lactate 0,31 mg/ml
7 Day

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