Last update :
03/05/2024
References   References 743  
Type : Journal

Research teams : Mac Gaw Park - American Critical Care
Authors : Lee YC, Baaske DM, Amann AH, Carter JE, Mooers MA, Wagenknecht DM, Lai CM.
Title : Bretylium tosylate intravenous admixture compatibility. I: Stability in common large-volume parenteral solutions.
Reference : Am J Hosp Pharm ; 37: 803-808. 1980

Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionBretylium tosilate Anti-arrhythmic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 40°C Protect from light
48 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
7 Day
Stability in solutions Glass Ringer’s lactate solution 10 mg/ml 25°C Light
48 Hour
Stability in solutions Glass Ringer’s lactate solution 10 mg/ml 40°C Protect from light
48 Hour
Stability in solutions Glass Ringer’s lactate solution 10 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 40°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 10 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 10 mg/ml 40°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 10 mg/ml 4°C Protect from light
7 Day

  Mentions Légales