Last update :
28/04/2024
References   References 683  
Type : Journal

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Lau DWC, DeAngelis C, Iazetta J, Coons C.
Title : Epirubicin stability in syringes and glass vials and evaluation of chemical contamination.
Reference : Can J Hosp Pharm ; 43: 265-272. 1990

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Search of DEHP 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionEpirubicin hydrochloride Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 1 & 2 mg/ml 23°C Not specified
150 Day
Stability in solutions Glass Sodium chloride 0,9% 1 & 2 mg/ml 4°C Protect from light
150 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml 23°C Protect from light
150 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml 4°C Protect from light
150 Day

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