Last update :
29/10/2024
References   References 681  
Type : Journal

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker S, Lau D, DeAngelis C, Iazetta J, Coons C.
Title : Doxorubicin stability in syringes and glass vials and evaluation of chemical contamination.
Reference : Can J Hosp Pharm ; 44: 71-78. 1991

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Search of DEHP 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products identified and quantified
Unencrypted results (eg graphic)

List of drugs
injectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 2 mg/ml 23°C Light
124 Day
Stability in solutions Glass Sodium chloride 0,9% 2 mg/ml 4°C Light
124 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml 23°C Light
124 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml 4°C Protect from light
124 Day

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