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References   References 644  
Type : Journal
Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Marble DA, Bosso JA, Townsend RJ.
Title : Compatibility of clindamycin phosphate with aztreonam in polypropylene syringes and with cefoperazone sodium, cefonicid sodium, and cefuroxime sodium in partial-fill glass bottles.
Reference : Drug Intell Clin Pharm ; 22: 54-57. 1988
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
List of drugs
injectionAztreonam Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 20 mg/ml 25°C Light
48 Hour
Compatible 200 mg/ml + injectionClindamycin phosphate 60 mg/ml + Sodium chloride 0,9%
injectionCefonicid sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Compatible 10 mg/ml + injectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefoperazone sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + injectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefuroxime sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 15 mg/ml 25°C Light
48 Hour
Compatible 15 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionClindamycin phosphate Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 60 mg/ml 25°C Light
48 Hour
Compatible 60 mg/ml + injectionAztreonam 200 mg/ml + Sodium chloride 0,9%
Compatible 12 mg/ml + injectionCefonicid sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 12 mg/ml + injectionCefoperazone sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + injectionCefuroxime sodium 15 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 12 mg/ml
injection Cefoperazone sodium 20 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 12 mg/ml
injection Cefonicid sodium 10 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Cefuroxime sodium 15 mg/ml
48 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Clindamycin phosphate 60 mg/ml
injection Aztreonam 200 mg/ml
48 Hour
  Mentions Légales