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References   References 631  
Type : Journal
Research teams : Houston - University of Houston, College of Pharmacy
Authors : Das Gupta V, Stewart KR.
Title : Chemical stabilities of hydrocortisone sodium succinate and several antibiotics when mixed with metronidazole injection for intravenous infusion.
Reference : J Parenter Sci Technol ; 39: 145-148. 1985
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Stability indicating capability inadequately assessed
List of drugs
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionCefalotin sodium Antibiotic
Compatible 20 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionCefazolin sodium Antibiotic
Compatible 10 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionCefoxitin sodium Antibiotic
Compatible 30 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 10 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionAmpicillin sodium 20 mg/ml + None
Compatible 5 mg/ml + injectionCefalotin sodium 20 mg/ml + None
Compatible 5 mg/ml + injectionCefazolin sodium 10 mg/ml + None
Compatible 5 mg/ml + injectionCefoxitin sodium 30 mg/ml + None
Compatible 5 mg/ml + injectionHydrocortisone sodium succinate 10 mg/ml + None
Compatible 5 mg/ml + injectionMoxalactam 20 mg/ml + None
Compatible 5 mg/ml + injectionPenicillin G potassium 0.2 MUI/ml + None
injectionMoxalactam Antibiotic
Compatible 20 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionPenicillin G potassium Antibiotic
Compatible 0.2 MUI/ml + injectionMetronidazole 5 mg/ml + None
Stability of mixtures
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Cefoxitin sodium 30 mg/ml
2 Day
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Cefoxitin sodium 30 mg/ml
2 Day
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Moxalactam 20 mg/ml
2 Day
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Penicillin G potassium 0,2 MUI/ml
3 Day
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Cefazolin sodium 10 mg/ml
7 Day
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Hydrocortisone sodium succinate 10 mg/ml
7 Day
Glass None 25°C Protect from light
injection Metronidazole 5 mg/ml
injection Ampicillin sodium 20 mg/ml
22 Hour
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Ampicillin sodium 20 mg/ml
12 Day
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Cefazolin sodium 10 mg/ml
12 Day
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Cefoxitin sodium 30 mg/ml
12 Day
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Cefalotin sodium 20 mg/ml
12 Day
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Hydrocortisone sodium succinate 10 mg/ml
12 Day
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Penicillin G potassium 0,2 MUI/ml
12 Day
Glass None 5°C Protect from light
injection Metronidazole 5 mg/ml
injection Moxalactam 20 mg/ml
12 Day
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