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References   References 630  
Type : Journal
Research teams : Houston - University of Houston, College of Pharmacy
Authors : Das Gupta V, Stewart KR.
Title : Stability of metronidazole and ten antibiotics when mixed with magnesium sulphate solutions.
Reference : J Clin Hosp Pharm ; 10: 67-72. 1985
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
injectionAmpicillin sodium Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Sodium chloride 0,9%
injectionCefamandole nafate Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionCefazolin sodium Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionCefoxitin sodium Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 10 & 20 mg/ml + injectionAmpicillin sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 10 & 20 mg/ml + injectionCefamandole nafate 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + injectionCefazolin sodium 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + injectionCefoxitin sodium 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + injectionMetronidazole 2 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + injectionMoxalactam 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + injectionNafcillin sodium 5 mg/ml + Glucose 5%
Incompatible 10 & 20 mg/ml + injectionPenicillin G potassium + Glucose 5%
Compatible 10 & 20 mg/ml + injectionPiperacillin sodium 5 mg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 2 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionMoxalactam Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionNafcillin sodium Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionPenicillin G potassium Antibiotic
Incompatible + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
injectionPiperacillin sodium Antibiotic
Compatible 5 mg/ml + injectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Protect from light
injection Metronidazole 2 mg/ml
injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
injection Cefamandole nafate 5 mg/ml
injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
injection Cefazolin sodium 5 mg/ml
injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
injection Piperacillin sodium 5 mg/ml
injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
injection Cefoxitin sodium 5 mg/ml
injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
injection Moxalactam 5 mg/ml
injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
  Mentions Légales