Last update :
03/05/2024
References   References 558  
Type : Journal

Research teams : Nottingham - Nottingham City Hospital, Quality Control Laboratory
Authors : Kirk B.
Title : Stability of reconstituted mustine injection BP during storage.
Reference : Br J Parent Ther ; july/august : 86-92. 1986

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Electrochemical detector
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No visual inspection
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionChlormethine hydrochloride Anticancer drug
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability PH Increase Induces Degradation
Stability in solutions Glass Water for Injection 1 mg/ml 21°C-23°C Not specified
6 Hour
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
6 Hour
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 21°C-23°C Not specified
6 Hour
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 4°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,02 mg/ml 21°C-23°C Not specified
3 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,02 mg/ml 4°C Protect from light
3 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 0,02 mg/ml 21°C-23°C Not specified
4 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 0,02 mg/ml 4°C Protect from light
6 Hour

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