Last update :
19/11/2024
References   References 525  
Type : Journal

Research teams : Ghent - laboratory of Pharmaceutical technology, State University of Gent
Authors : De Vroe C, De Muynck C, Remon JP, Samsom M.
Title : A study on the stability of three antineoplastic drugs and on their sorption by IV delivery systems and end-line filters.
Reference : Int J Pharm ; 65: 49-56. 1990

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection
No comments for the degradation products

List of drugs
injectionEpirubicin hydrochloride Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,05 mg/ml 4°C Protect from light
25 Day
Stability in solutions Glass Glucose 5% 0,05 mg/ml 4°C Protect from light
30 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,05 mg/ml 4°C Protect from light
25 Day
Stability in solutions Polyvinyl chloride Glucose 5% 0,05 mg/ml 4°C Protect from light
30 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0,05 mg/ml 4°C Protect from light
25 Day
Stability in solutions Polyethylene Glucose 5% 0,05 mg/ml 4°C Protect from light
30 Day
injectionNimustine Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 2 mg/ml 25°C Protect from light
7 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 2 mg/ml 4°C Protect from light
6 Day
Stability in solutions Glass Sodium chloride 0,9% 2 mg/ml 25°C Light
5 Hour
Stability in solutions Glass Glucose 5% 2 mg/ml 25°C Light
7 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 2 mg/ml 4°C Protect from light
6 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 2 mg/ml 4°C Protect from light
6 Day

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