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References   References 5157  
Type : Journal
Web link : doi:10.1136/ejhpharm-2024-004346
Research teams : Lausanne - University Hospital, Department of Pharmacy
Authors : Bello W, Hosotte C, Stampfli C, Pierrot A, Munier F L, Berger-Gryllaki M, Pezzatti J, Carrez L, Sadeghipour F.
Title : Stability study of topotecan in ophthalmic prefilled syringes for intravitreal delivery
Reference : EJHP 33:67-72 2025
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified
List of drugs
injectionTopotecan Anticancer drug
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml -25 > -15°C Protect from light
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml 2-8°C Protect from light
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml 28-32°C Protect from light
180 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml -25 > -15°C Protect from light
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 2-8°C Protect from light
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 28-32°C Protect from light
365 Day
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