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References   References 5156  
Type : Journal
Web link : doi:10.1136/ejhpharm-2024-004177
Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : St-Jean I, Hachemi D, Friciu M, Forest JM, Belliveau M, Williamson D, Leclair G.
Title : Stability of dexmedetomidine, ketamine and lidocaine combined injectable solution for analgesia
Reference : EJHP 33:80-85 2026
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionDexmedetomidine Sympathomimetic
injectionKetamine hydrochloride General anesthetic
injectionLidocaine hydrochloride Local anesthetic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 21°C Light
injection Dexmedetomidine 1 µg/ml
injection Ketamine hydrochloride 1 mg/ml
injection Lidocaine hydrochloride 10 mg/ml
3 Day
Polypropylen Syringe Sodium chloride 0,9% 5°C Light
injection Dexmedetomidine 1 µg/ml
injection Ketamine hydrochloride 1 mg/ml
injection Lidocaine hydrochloride 10 mg/ml
9 Day
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