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References   References 5133  
Type : Journal
Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Devis L, Colsoul ML, Bihin B, Jamart J, Soumoy L, Lombet L, Hecq JD, Galanti L, Closset M, Catry E.
Title : Long-Term Physicochemical Stability of a Morphine-Ketamine Admixture in Polypropylene Syringes at Room Temperature.
Reference : Int J Pharm Compound ;29,5:439-446 2025
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Method not shown but the article refers to a validated method
List of drugs
injectionKetamine hydrochloride General anesthetic
Compatible 3,3 mg/ml + injectionMorphine hydrochloride 2 mg/ml + Sodium chloride 0,9%
injectionMorphine hydrochloride Analgesic
Compatible 2 mg/ml + injectionKetamine hydrochloride 3,3 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 19-25°C Protect from light
injection Morphine hydrochloride 2 mg/ml
injection Ketamine hydrochloride 3,3 mg/ml
49 Day
  Mentions Légales