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References   References 4943  
Type : Journal
Web link : https://doi.org/10.3390/antibiotics14050466
Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : D'Huart E, Boutouha I, Berardi C, Vigneron J, Demore B, Charmillon A.
Title : Stability of Nine Time-Dependent Antibiotics for Outpatient Parenteral Antimicrobial Therapy (OPAT) Use
Reference : Antibiotics Antibiotics 2025, 14(5), 2025
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionAmoxicillin sodium Antibiotic
Stability in solutions Silicone elastomer Sodium chloride 0,9% 12,5 mg/ml 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 25 mg/ml 32°C Protect from light
8 Hour
injectionCefepime dihydrochloride Antibiotic
Stability in solutions Silicone elastomer NaCl 0,9% or Glucose 5% 12,5 mg/ml 32°C Protect from light
12 Hour
injectionCefiderocol sulfate tosylate Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Reduced stability
Stability in solutions Silicone elastomer Sodium chloride 0,9% 12,5 mg/mL 32°C Protect from light
24 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 25 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Glucose 5% 12,5 & 25 mg/mL 32°C Protect from light
12 Hour
injectionCefotaxime sodium Antibiotic
Stability in solutions Silicone elastomer NaCl 0,9% or Glucose 5% 12,5 mg/ml 32°C Protect from light
12 Hour
injectionCefoxitin sodium Antibiotic
Stability in solutions Silicone elastomer NaCl 0,9% or Glucose 5% 12,5 mg/ml 32°C Protect from light
12 Hour
injectionCeftazidime Antibiotic
Stability in solutions Silicone elastomer NaCl 0,9% or Glucose 5% 12,5 mg/ml 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 25 mg/ml 32°C Protect from light
8 Hour
injectionCloxacillin sodium Antibiotic
Stability in solutions Silicone elastomer NaCl 0,9% or Glucose 5% 25 mg/ml 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 50 mg/ml 32°C Protect from light
8 Hour
injectionOxacillin sodium Antibiotic
Stability in solutions Silicone elastomer Sodium chloride 0,9% 25 & 50 mg/ml 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Glucose 5% 25 mg/ml 32°C Protect from light
8 Hour
injectionPiperacillin sodium Antibiotic
Stability in solutions Silicone elastomer NaCl 0,9% or Glucose 5% 50 & 133 mg/ml 32°C Protect from light
24 Hour
  Mentions Légales