Last update :
27/11/2025
References   References 4922  
Type : Journal
Web link : https://doi.org/10.1016/j.jaip.2024.10.040

Research teams : Hobart - University of Tasmania, School of Pharmacy
Authors : Wanandy T, Handley SA, Le TTA, Lau WY, Turner ME, Wiese MD.
Title : Stability of Antibiotics for Use in the Testing of Immediate Drug Allergy Reactions.
Reference : J Allergy Clin Immunol Pract 13, 2: 343-352. 2024

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Increased concentration unexplained

List of drugs
injectionAmoxicillin sodium Antibiotic
Stability in solutions Glass Water for Injection 20 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
1 Day
Stability in solutions Polypropylen Syringe Water for Injection 20 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
1 Day
injectionAmoxicillin sodium / clavulanic acid Antibiotic
Stability in solutions Polypropylen Syringe Water for Injection 25/5 mg/ml 2-8°C Protect from light
4 Hour
injectionAmpicillin sodium Antibiotic
Stability in solutions Glass Water for Injection 25 mg/ml 2-8°C Protect from light
2 Day
injectionAztreonam Antibiotic
Stability in solutions Glass Water for Injection 2 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 2 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 2 mg/ml 2-8°C Protect from light
7 Day
injectionCefazolin sodium Antibiotic
Stability in solutions Glass Water for Injection 33 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 33 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Water for Injection 33 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 33 mg/ml 2-8°C Protect from light
7 Day
injectionCefepime dihydrochloride Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 2 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 2 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 2 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 2 mg/ml 2-8°C Protect from light
2 Day
injectionCefotaxime sodium Antibiotic
Stability in solutions Glass Water for Injection 20 mg/ml 2-8°C Protect from light
1 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
1 Day
Stability in solutions Polypropylen Syringe Water for Injection 20 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
7 Day
injectionCeftazidime Antibiotic
Stability in solutions Glass Water for Injection 20 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Water for Injection 20 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
2 Day
injectionCeftriaxone disodium Antibiotic
Stability in solutions Glass Water for Injection 20 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Water for Injection 20 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 20 mg/ml 2-8°C Protect from light
2 Day
injectionCiprofloxacin lactate Antibiotic
Stability in solutions Glass Water for Injection 0,02 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 0,02 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe Water for Injection 0,02 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 0,02 mg/ml 2-8°C Protect from light
7 Day
injectionCo-trimoxazole Antibiotic
Stability in solutions Glass Water for Injection 0,8/1,6 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 0,8/1,6 mg/ml 2-8°C Protect from light
2 Day
injectionFlucloxacillin sodium Antibiotic
Stability in solutions Glass Water for Injection 5 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 5 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe Water for Injection 5 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 5 mg/ml 2-8°C Protect from light
2 Day
injectionMeropenem Antibiotic
Stability in solutions Glass Water for Injection 1 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 1 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Water for Injection 1 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 1 mg/ml 2-8°C Protect from light
2 Day
injectionPenicillin G sodium Antibiotic
Stability in solutions Glass Water for Injection 0.01 MUI/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 0.01 MUI/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Water for Injection 0.01 MUI/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 0.01 MUI/ml 2-8°C Protect from light
2 Day
injectionPiperacillin sodium / tazobactam Antibiotic
Stability in solutions Glass Water for Injection 20/2,5 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 20/2,5 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe Water for Injection 20/2,5 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 20/2,5 mg/ml 2-8°C Protect from light
2 Day
injectionVancomycin hydrochloride Antibiotic
Stability in solutions Glass Water for Injection 0,005 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0.9% + phenol 0.4% 0,005 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe Water for Injection 0,005 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0.9% + phenol 0.4% 0,005 mg/ml 2-8°C Protect from light
7 Day

  Mentions Légales