Last update :
26/03/2025
References   References 4892  
Type : Journal
Web link : https://doi.org/10.1002/ardp.202300072

Research teams : Kiel - Christian-Albrechts- University Kiel, Pharmaceutical Institute
Authors : Jirschitzka S, Längle D, Lück H, Schade D, Schade T.
Title : Combined physicochemical and functional assessment of pertuzumab integrity supports extended in‐use stability.
Reference : Arch Pharm ;356:e2300072. 2023

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: Peptide mapping
Protein: ultraviolet spectrometry and second derivative
Other methods : 
PH measurement 
Comments : 
Proteins: biological activity by cell culture

List of drugs
injectionPertuzumab Anticancer drug
Stability in solutions partially used vials None 30 mg/ml 2-6°C Light
42 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1,59 mg/ml 17-23°C Light
28 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1,59 mg/ml 2-6°C Light
28 Day

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