Last update :
28/04/2024
References   References 481  
Type : Journal PC : 0.0006830601092896 

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Beijnen JH, Vendrig DEMM, Underberg WJM.
Title : Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids.
Reference : J Parenter Sci Technol ; 43: 84-87. 1989

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No visual inspection
No comments for the degradation products

List of drugs
InjectionVinblastine sulfate Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 4°C Protect from light
21 Day
InjectionVincristine sulfate Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 4°C Protect from light
21 Day
InjectionVindesine sulfate Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 4°C Protect from light
21 Day

  Mentions Légales