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References   References 4745  
Type : Journal
Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Vieillard V, Paul M
Title : Physicochemical stability study of a biosimilar of Bevacizumab in vials and after dilution in 0.9% NaCl in polyolefin intravenous bags.
Reference : Pharmaceutical Technology in Hospital Pharmacy 2023
Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
List of drugs
InjectionBevacizumab Anticancer drug
Stability in solutions Glass None 25 mg/ml 22-28°C Protect from light
15 Day
Stability in solutions Partially used vials None 25 mg/ml 2-8°C Protect from light
60 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Protect from light
90 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 22-28°C Protect from light
3 Day
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