Last update :
21/03/2023
References   References 4727  
Type : Journal

Research teams : Marseille - Hôpital de la Conception
Authors : Primas N, Lano G, Brun D, Curti C, Sallée M, Sampol-Manos E, Lamy E, Bornet C, Burtey S, Vanelle P.
Title : Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization
Reference : Pharmaceuticals ;16,72 2023

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionN-acetylcysteine Antidote
Stability in solutions Polyolefine Glucose 5% 25 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyolefine Glucose 5% 25 mg/ml 23-27°C Not specified
24 Hour
InjectionZinc gluconate Various
Stability of mixtures
Polyolefine Glucose 5% 2-8°C Protect from light
Injection N-acetylcysteine 25 mg/ml
Injection Zinc gluconate 62.5 µg/mL
8 Day
Polyolefine Glucose 5% 23-27°C Protect from light
Injection N-acetylcysteine 25 mg/ml
Injection Zinc gluconate 62.5 µg/mL
4 Day

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