Last update :
30/09/2022
References   References 4667  
Type : Journal

Research teams : Hebei - The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Authors : Ping L, juan H, Li R-L, Feng Z-Y, Zhou X-J, Liu M-F, Jing B, Jian L.
Title : Stability of Hydromorphone Hydrochloride and Morphine under Different Clinical Infusion Conditions.
Reference : Int J Pharm Pharm Sci ;81(6):1140-114 2019

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionHydromorphone hydrochloride Analgesic
InjectionMorphine hydrochloride Analgesic
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Not specified
Injection Hydromorphone hydrochloride 0,05 mg/ml
Injection Morphine hydrochloride 0,25 mg/ml
15 Day
Glass Sodium chloride 0,9% 37°C Not specified
Injection Hydromorphone hydrochloride 0,05 mg/ml
Injection Morphine hydrochloride 0,25 mg/ml
15 Day
Polyvinyl chloride Sodium chloride 0,9% 25°C Not specified
Injection Hydromorphone hydrochloride 0,05 mg/ml
Injection Morphine hydrochloride 0,25 mg/ml
15 Day
Polyvinyl chloride Sodium chloride 0,9% 37°C Not specified
Injection Hydromorphone hydrochloride 0,05 mg/ml
Injection Morphine hydrochloride 0,25 mg/ml
15 Day
Polyethylene Sodium chloride 0,9% 25°C Not specified
Injection Morphine hydrochloride 0,25 mg/ml
Injection Hydromorphone hydrochloride 0,05 mg/ml
15 Day
Polyethylene Sodium chloride 0,9% 37°C Not specified
Injection Hydromorphone hydrochloride 0,05 mg/ml
Injection Morphine hydrochloride 0,25 mg/ml
15 Day

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