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References   References 4641  
Type : Journal
Web link : https://doi.org/10.1016/j.ejps.2021.106039
Research teams : Milan - Universit`a degli Studi di Milano ,Milan, Italy
Authors : Zanon D, Selmin F, Centin G, Maximova N, Casiraghi A, Minghetti P.
Title : Stability of high concentrated triple intrathecal therapy for pediatrics and mitigation strategies.
Reference : Eur J Pharm Sci ;167: 106039. 2021
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
List of drugs
injectionHydrocortisone sodium succinate Anti-inflammatory
injectionMethotrexate sodium Anticancer drug
injectionMethylprednisolone sodium succinate Anti-inflammatory
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 24-26°C Protect from light
injection Methotrexate sodium 5,3 mg/ml
injection Methylprednisolone sodium succinate 0,8 mg/ml
6 Hour
Polypropylen Syringe Sodium chloride 0,9% 24-26°C Protect from light
injection Methotrexate sodium 3 mg/ml
injection Methylprednisolone sodium succinate 0,5 mg/ml
6 Hour
Polypropylen Syringe Sodium chloride 0,9% 24-26°C Protect from light
injection Methotrexate sodium 6 mg/ml
injection Hydrocortisone sodium succinate 4 mg/ml
24 Hour
Polypropylen Syringe Sodium chloride 0,9% 24-26°C Protect from light
injection Methotrexate sodium 3 mg/ml
injection Hydrocortisone sodium succinate 2,5 mg/ml
24 Hour
  Mentions Légales