Last update :
15/10/2021
References   References 4602  
Type : Journal
Web link : https://journals.sagepub.com/doi/10.1177/0018578719888912

Research teams : Rochester - St. John Fisher College, Rochester, NY, USA
Authors : Buga I, Uzoma J.I, Reindel K, Rashid K, Diep T, McCartan P, Zhao F.
Title : Physical and Chemical Stability of Dexamethasone Sodium Phosphate in Intravenous Admixtures Used to Prevent Chemotherapy-Induced Nausea and Vomiting.
Reference : Hosp Pharm ; 56, 4: 215-220. 2021

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionDexamethasone sodium phosphate Anti-inflammatory
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,08 mg/ml 2-8°C Not specified
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,08 mg/ml 20-23°C Not specified
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 mg/ml 2-8°C Not specified
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 mg/ml 20-23°C Not specified
14 Day

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